Independent Career:

25. Proteomic and functional analyses of the periodic membrane skeleton in neurons.

R Zhou, B Han, R Nowak, Y Lu, E Heller, C Xia, AH Chishti, VM Fowler, X Zhuang. Nature Communications 13, 3196 (2022)

Prior to Penn State:

Selected publications:

24. Membrane-associated periodic skeleton is a signaling platform for RTK transactivation in neurons.

R Zhou, B Han, C Xia, X Zhuang. Science 365, 929-934 (2019)

Highlighted in Nature Reviews Neuroscience 20, 647 (2019): A platform for coordinated signalling

23. Junction resolving enzymes use multivalency to keep the Holliday junction dynamic.

R Zhou (co-corresponding author), O Yang, AC Déclais et al. Nature Chemical Biology 15, 269-275 (2019)

Highlighted in Nature Chemical Biology 15, 209-210 (2019): Freedom of movement

22. Visualizing and discovering cellular structures with super-resolution microscopy.

Y Sigal, R Zhou, X Zhuang. Science 361, 880-887 (2018)

21. Structural organization of the actin-spectrin–based membrane skeleton in dendrites and soma of neurons

B Han, R Zhou (co-first author, co-corresponding author), C Xia, X Zhuang. PNAS 114,6678-6685 (2017)

20. Prevalent presence of periodic actin-spectrin-based membrane skeleton in a broad range of neuronal cell types and animal species.

J He, R Zhou (co-first author), Z Wu et al. PNAS 113, 6029-6034 (2016)

19. Real-time imaging of translation on single mRNA transcripts in live cells.

C Wang, B Han, R Zhou, X Zhuang. Cell 165, 990-1001 (2016)

18. Asymmetric unwrapping of nucleosomes under tension directed by DNA local flexibility.

TTM Ngo, Q Zhang, R Zhou, JG Yodh and T Ha. Cell 160, 1135-1144 (2015)

Highlighted in Cell 160, 1139-1140 (2015): A Molecular Take on Aesop’s The Oak and the Reeds.

17. Periodic DNA patrolling underlies diverse functions of Pif1 on R-loops and G-rich DNA.

R Zhou, J Zhang, ML Bochman, VA Zakian and T Ha. eLife 3, e02190 (2014)

Highlighted in eLife 3, e02854 (2014): DNA Helicases: Molecular watchdogs on genome patrol

16. Detecting intramolecular conformational dynamics of single molecules in short distance range with sub-nanometer sensitivity.

R Zhou, S Kunzelmann, M Webb, T Ha. Nano Letters 11, 5482-5488 (2011)

15. SSB functions as a sliding platform that migrates on DNA via reptation.

R Zhou, AG Kozlov, R Roy, J Zhang, S Korolev, TM Lohman and T Ha. Cell 146, 222-232 (2011)

Selected as: the Cell PaperFlick (video) of the issue (Watch on Youtube)

14. Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics.

C Grashoff , BD Hoffman, MD Brenner, R Zhou, M Parsons, MT Yang, M A. McLean, SG Sligar, CS Chen, T Ha and MA Schwartz. Nature 466, 263–266 (2010)

Highlighted in Nature 466, 192–193 (2010): Sensing tension

13. Fluorescence-force spectroscopy maps two-dimensional reaction landscape of the Holliday junction.

S Hohng, R Zhou, MK Nahas, J Yu, K Schulten, DMJ Lilley and T Ha. Science 318, 279-283 (2007)

Highlighted in Nature Methods 4, 986-987 (2007): Fluorescence-force spectroscopy: watch your tether

Other publications:

12. βII-spectrin promotes mouse brain connectivity through stabilizing axonal plasma membranes and enabling axonal organelle transport.

DN Lorenzo, A Badea, R Zhou et al. PNAS 116, 15686-15695 (2019)

11. Spider silk peptide is a compact, linear nanospring ideal for intracellular tension sensing.

MD Brenner, R Zhou, et al. Nano Letters 16, 2096-2102 (2016)

10. Developmental mechanism of the periodic membrane skeleton in axons.

G Zhong, J He, R Zhou, D. Lorenzo, HP Babcock, V Bennett, X Zhuang. eLife 3, e04581 (2015)

9. Structural mechanisms of PriA-mediated DNA replication restart.

B Bhattacharyya, NP George, TM Thurmes, R Zhou, N Jani, SR Wessel, SJ Sandler, T Ha and JL Keck. PNAS 111, 1373-1378 (2014)

8. An improved surface passivation method for single-molecule studies.

B Hua, KY Han, R Zhou, H Kim, X Shi, SC Abeysirigunawardena, A Jain, D. Singh, V. Aggarwal, SA Woodson and T Ha. Nature Methods 11, 1233-1236 (2014)

7. The Telomere Capping Complex CST Has an Unusual Stoichiometry, Makes Multipartite Interaction with G-Tails, and Unfolds Higher-Order G-Tail Structures.

NF Lue, R Zhou, L Chico, N Mao, O Steinberg-Neifach and T Ha. PLoS Genetics 9, e1003145 (2013)

6. The SOSS1 single-stranded DNA binding complex promotes DNA end resection in concert with Exo1.

SH Yang, R Zhou, J Campbell, J Chen, T Ha, and TT Paull. EMBO Journal 32, 126-132 (2013)

5. PriC-mediated DNA replication restart requires PriC complex formation with the single-stranded DNA-binding protein.

SR Wessel, AH Marceau, SC Massoni, R Zhou, T Ha, SJ Sandler and JL Keck. publisher of Biological Chemistry 288, 17569-17578 (2013)

4. Single molecule analysis of Thermus thermophilus SSB protein dynamics on single-stranded DNA.

J Zhang, R Zhou, J Inoue, T Mikawa, T Ha. Nucleic Acids Research 42, 3821-3832 (2013)

3. Single molecule analysis of SSB dynamics on DNA.

R Zhou, T Ha. Methods in Molecular Biology 922, 85-100 (2012)

2. Forcing a connection: Impacts of single-molecule force spectroscopy on in vivo tension sensing.

MD Brenner, R Zhou, and T Ha. Biopolymers 95, 332-344 (2011)

1. Fluorescence-force spectroscopy at the single molecule level.

R Zhou, M Schlierf, and T Ha. Methods in Enzymology 475C, 405-426 (2010)